So, will Manning make it through 2012 without being injured ? I am going to make a prediction here. Manning will be injured VS SF in his 8/26/12Preseason game. I don't think he could have drawn a worse defense to play against in his 3rd Preseason game. The starting QB usually plays the first half in the 3rd game. Manning doesn't make it out of the gates on opening day. Patrick Willis is my prediction for who will make the play off of the right side into the back of Manning. Any predictions?